Abstract #0087

Intravoxel Incoherent Motion Modeling Applied to Cardiac Diffusion Weighted MRI: Toward Free Breathing Acquisition in Healthy Volunteers

Bndicte MA Delattre¹, Magalie Viallon², Hui Xue³, Marie-Pierre Jolly³, Christoph Guetter³, Hongjiang Wei¹, Yuemin Zhu¹, Thorsten Feiweier⁴, Vinay M. Pai⁵, Han Wen⁵, Pierre Croisille¹,⁶

¹CREATIS, CNRS (UMR 5220), INSERM (U1044), INSA Lyon, University of Lyon, Lyon, France; ²Department of Radiology, University Hospitals of Geneva, Geneva, Switzerland; ³Siemens Corporate Research, Princeton, New Jersey 08540, United States; ⁴Siemens Healthcare , Erlangen, Germany; ⁵Imaging Physics Lab, BBC/NHLBI/NIH, Bethesda, Maryland 20892, United States; ⁶Jean-Monnet University, Saint-Etienne, France

Intravoxel Incoherent Motion (IVIM) model is currently a unique method for evaluating perfusion and diffusion parameters from DWI without the use of any contrast agent. Recently, an efficient cardiac DWI method was proposed where motion-induced signal-loss was compensated for by PCATMIP post-processing. While performing cardiac DWI acquisition using breath-hold yields accurate IVIM parameters, it can be difficult to apply in clinical routine. This study compares the IVIM parameters of perfusion fraction, diffusion coefficient and pseudo-diffusion coefficient estimated from PCATMIP-processed breath-hold and free breathing acquisitions. The results yield the possibility for acquiring perfusion measurements using free-breathing exams under non-contrast conditions.