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Abstract #0088

Apparent Diffusion Coefficient of Intramyocelluler Lipid in Heart Muscle

Victor B. Xie1, 2, Peng Cao1, 2, Zhong wei Qiao1, 2, Anna M. Wang1, 2, Shujuan Fan1, 2, Ed X. Wu1, 2

1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong SAR, China; 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong SAR, China

In this study, we investigated the intramyocellular lipid (IMCL) diffusion property in heart muscle. IMCL ADC was documented in fresh heart muscle samples at 80ms diffusion time, exhibiting slow and largely isotropic diffusion. IMCL ADC was found to be lower than that in skeletal muscle, which likely resulted from the smaller IMCL droplet size, i.e., more restricted diffusion. Such diffusion characterization of IMCL heart muscle may provide insights in study of the IMCL droplet microstructure and lipid dynamics in heart muscle.