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Abstract #0130

Decreased GABA in the Anterior Cingulate Cortex of Female Borderline Personality Disorder Patients

Gabriele Ende1, Markus Sack1, Nuran Tunc-Skarka1, Wolfgang Weber-Fahr1, Mareen Hoerst1, Anne Krause-Utz2, Anne-Christine Reitz2, Sylvia Cackowski2, Christian Schmahl2

1Neuroimaging, Central Institute of Mental Health, Mannheim, Germany; 2Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany

Dysfunction and deficits in the structure of the anterior cingulate cortex as well as increased impulsivity have been reported in borderline personality disorder (BPD). Loss or dysfunction of GABAergic neurotransmission is associated with many neurological and psychiatric conditions. We report first GABA data from the ACC of 20 female BPD patients and 24 female healthy controls from an ongoing study. Two MEGA-PRESS edited spectra were obtained: with and without macromolecule (MM) suppression. Decreased GABA was found in the MM suppressed GABA data concordant with functional deficits observed in BPD patients.