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Abstract #0131

Individualized Mapping of the Subgenual Cingulate in Individual Unipolar Depressed Patients Using fMRI

Leslie Baxter1, Gary Grove2, Ryan Smith1, Perri Handley1, Michael Purcell1, Francisco Ponce3, Robert Spetzler3

1Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ, United States; 2Private Practice, Scottsdale, AZ, United States; 3Neurosurgery, Barrow Neurological Institute, Phoenix, AZ, United States

Deep Brain Stimulation is a new intervention for treating severe depression; however, response rates may be improved with fMRI if the region in the dysfunctional subgenual cingulate is better targeted. We developed a novel fMRI sadness induction paradigm that collects standardized blocks of data within a flexible-block design. Specifically, when subjects attain the targeted emotional state (sad or neutral), they trigger a standardized 30 block through a button press. Only those blocks are analyzed in the post-processing steps. Our preliminary data show that depressed patients can perform this task and generally show greater subgenual responsivity compared to controls.