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Abstract #0181

Imaging of Prostate Cancer Metabolic Heterogeneity with CEST & MT MRI

SUMMA25Kejia Cai1, He N. Xu, Anup Singh1, Mohammad Haris1, Ravinder Reddy1, Lin Z. Li

1CMROI, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States

Here we report the preliminary data on chemical exchange saturation transfer (CEST) & magnetization transfer (MT) magnetic resonance imaging (MRI) and redox scanning of two aggressive human prostate tumor lines (PC-3 and DU-145) xenografted in athymic nude mice. The results obtained by these methods appeared to be consistent with all showing higher level of heterogeneity in DU-145 tumors than in PC-3 tumors at this stage of tumor progression. MT and CEST MRI method could serve as a surrogate metabolic imaging biomarkers for redox imaging of tumor metastatic potential.