Simon Walker-Samuel1, Rajiv Ramasawmy1, Francisco Torrealdea2, Marilena Rega2, Peter Johnson3, Vineeth Rajkumar3, Simon Richardson1, Dave Thomas2, Barbara Pedley3, Mark F. Lythgoe1, Xavier Golay2
1Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom; 2Institute of Neurology, University College London, United Kingdom; 3Cancer Institute, University College London, United Kingdom
We have recently developed a technique named glucoseCEST that enables the accumulation of exogeneously administered, unlabelled glucose to be detected in tumours. Here we present a technique that allows glucoseCEST measurements to be converted to an absolute glucose concentration. This approach is evaluated in two colorectal tumour xenograft models (SW1222 and LS174T) and compared with 18F-FDG autoradiography. Significant differences in uptake were observed between tumour cell lines in both FDG and glucose measurements. Median tumour glucose and FDG concentrations were also significant correlated. These results suggest that glucoseCEST and 18F-FDG autoradiogaphy (and therefore FDG-PET) may provide corresponding information.