Abstract #0183

DCE-MRI & ICP-MS Evaluation of Biodistribution of Contrast Agents & Chemotherapeutic Agents to Gliomas with a New Pharmacological Approach in F98 Glioma Cells Implanted Fischer Rats

Jerome Cote¹, Luc Tremblay², David Fortin³, Fernand Gobeil⁴, Martin Lepage²

¹CIMS, Universit de Sherbrooke, Sherbrooke, Quebec, Canada; ²CIMS, Universit de Sherbrooke, Sherbrooke, Qubec, Canada; ³Chirurgie, Universit de Sherbrooke, Sherbrooke, Qubec, Canada; ⁴Pharmacologie, Universit de Sherbrooke, Sherbrooke, Qubec, Canada

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with intravenous Gd-DTPA or Gadomer was used to monitor the selective increase of blood-brain barrier permeability at the tumor of glioma-bearing rats, induced by a novel pharmacological approach. Our results indicate that the biodistribution of both contrast agents within rat gliomas and surrounding brain tissues was doubled. This was confirmed by a two-fold increase (versus vehicle) of concentrations of Gd-DTPA and Carboplatin in tumor and peripheral tissues measured by inductively coupled plasma mass spectrometry (ICP-MS).