Jerome Cote1, Luc Tremblay2, David Fortin3, Fernand Gobeil4, Martin Lepage2
1CIMS, Universit de Sherbrooke, Sherbrooke, Quebec, Canada; 2CIMS, Universit de Sherbrooke, Sherbrooke, Qubec, Canada; 3Chirurgie, Universit de Sherbrooke, Sherbrooke, Qubec, Canada; 4Pharmacologie, Universit de Sherbrooke, Sherbrooke, Qubec, Canada
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with intravenous Gd-DTPA or Gadomer was used to monitor the selective increase of blood-brain barrier permeability at the tumor of glioma-bearing rats, induced by a novel pharmacological approach. Our results indicate that the biodistribution of both contrast agents within rat gliomas and surrounding brain tissues was doubled. This was confirmed by a two-fold increase (versus vehicle) of concentrations of Gd-DTPA and Carboplatin in tumor and peripheral tissues measured by inductively coupled plasma mass spectrometry (ICP-MS).