Amit Mehndiratta1, Bradley J. MacIntosh2, David E. Crane2, Stephen J. Payne3, Michael A. Chappell3
1Institute of Biomedical Engineering , University of Oxford, Oxford, Oxfordshire, United Kingdom; 2Medical Biophysics, University of Toronto, Toronto, ON, Canada; 3Institute of Biomedical Engineering, University of Oxford, Oxford, Oxfordshire, United Kingdom
DSC-MRI analysis is an ill-posed inverse problem involving deconvolution of the observed MR signal with an AIF. The current standard SVD methods underestimate perfusion with an oscillatory residue function whereas the alternative vascular model-based (VM) approach permits only predefined shapes that may not be appropriate in pathology. Here we propose a deconvolution method that can estimate perfusion along with a physiological plausible residue function without any bias to a specific class of functional shapes. Our results showed the perfusion estimates were comparable to VM and the method formulation ensures physiologically realistic smooth functions.