Meeting Banner
Abstract #0198

Characterizing the Susceptibility Calibration Factor in Heterogeneous Vascular Networks

MAGNA25Natenael B. Semmineh1, Junzhong Xu, C Chad Quarles2

1institute of imaging science, Vanderbilt University, nashville, TN, United States; 2institute of Imaging science, Vanderbilt University, Nasville, TN

The use of DSC-MRI in tumors can be confounded by the assumption that a linear relationship, with a spatially uniform rate constant termed the vascular susceptibility calibration factor (kp), exists between the contrast agent (CA) concentration and the measured transverse relaxation rate change. Using simulations we demonstrate that vascular susceptibility calibration factors found in tumor-like vessel trees are significantly different than those found in normal tissue.