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Abstract #0199

In Vivo Imaging of Vessel Diameter, Size & Density: A Comparative Study between MRI & Histology

Benjamin Lemasson1, 2, Samuel Valable1, 3, Rgine Farion1, 2, Alexandre Krainik1, 2, Chantal Rmy1, 2, Emmanuel L. Barbier1, 2

1U836, Inserm, Grenoble, France; 2Grenoble Institut des Neurosciences, Universit Joseph Fourier, Grenoble, France; 3UMR 6232, CNRS, Caen, France

The purpose of the study was to compare MRI and histological estimates of the mean vessel diameter (mVD), the vessel density (Density), and the vessel size index (VSI) obtained in the same tumor-bearing animals (C6 and RG2 models). MRI and histology differed by -15 to 26%. A positive correlation was found between MRI and histology for mVD, Density, and VSI counterparts (R=0.62, 0.50, 0.73, respectively; p<0.001 in all cases). As Density and mVD or VSI provide complementary information, it is worth computing them to characterize angiogenesis beyond blood volume fraction.