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Abstract #0241

Comparison of Signal Intensity & Standard Techniques for Estimation of Pharmacokinetic Parameters in DCE-T1 Studies of Glioblastoma: Using Model Selection

Hassan Bagher-Ebadian1, 2, Siamak P. Nejad-Davarani1, 3, Rajan Jain4, Douglas Noll3, Quan Jiang1, Ali Syed Arbab4, Tom Mikkelsen5, James R. Ewing1, 2

1Neurology, Henry Ford Hospital, Detroit, MI, United States; 2Physics, Oakland University, Rochester, MI, United States; 3Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States; 4Radiology, Henry Ford Hospital, Detroit, MI, United States; 5Neurosurgery, Henry Ford Hospital, Detroit, MI, United States

DCE-pharmacokinetic models rely on the construction of an observation equation which demands conversion of the measured signal intensity (SI) profile into an indicator concentration time-course. Recent studies have proposed that the normalized SI [(St-S0)/S0] be used instead of the longitudinal-relaxation-rate change (ΔR1) in DCE-MRI permeability analyses. However, we know of no assessment of the agreement in the estimated permeability parameters using different measures of concentrations (SI-ΔR1). The goal of this study is to evaluate the use of SI, as opposed to ΔR1, in the estimation of permeability parameters in DCE-T1-3D-Spoiled-Gradient-Echo studies in the brains of ten treatment-nave patients with glioblastoma.