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Abstract #0240

Reproducibility of Dynamic Contrast-Enhanced MRI Perfusion Parameters on Various Computer Aided Diagnosis Workstations: Taking a Peek Into the Black Box.

MAGNA25Tobias Heye1, Matthew Davenport2, Jeff Horvath1, Sebastian Feuerlein1, Steven Breault1, Mustafa Bashir1, Elmar M. Merkle1, Daniel T. Boll1

1Department of Radiology, Duke University Medical Center, Durham, NC, United States; 2Department of Radiology, University of Michigan Health System, Ann Arbor, MI, United States

Although many factors contributing to overall measurement error have been identified, the effect of commercially available DCE-MRI post-processing solutions on quantitative (Ktrans, kep, ve) and semi-quantitative (iAUGC) pharmacokinetic parameters has yet to be defined. This study assessed the reproducibility of pharmacokinetic parameters between various commercially available post-processing solutions for DCE-MRI (Tissue4DTM, Siemens, Germany; DynaCADTM, Invivo, USA; AegisTM, Sentinelle Medical, Canada; CADvueTM; iCAD, Inc., USA). There is substantial variability (25.1-74.1% coefficient of variation) for DCE-MRI pharmacokinetic parameters across commercially available DCE-MRI post-processing solutions. If DCE-MRI is to succeed as a widely incorporated biomarker, the industry must agree on a post-processing standard.