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Abstract #0239

Estimation of the Arterial Input Function in a Mouse Tail from the Signal Phase of Projection Profiles

Jennifer Moroz1, Andrew Yung1, Piotr Kozlowski1, Stefan Reinsberg1

1Physics and Astronomy, University of British Columbia, Vancouver, British Columbia, Canada

Quantitative DCE-MRI analysis requires an accurate measure of the arterial input function (AIF). The AIF should have a high temporal resolution and be acquired for each experiment. However, AIF acquisition in mice is challenging because of their small size and rapid heart rates. This work demonstrates that a high temporal resolution AIF may be determined from a series of projection scans using phase data. An AIF in a mouse tail, having a temporal resolution of 100 ms, was successfully measured. The results suggest that rapid AIF acquisition in a mouse is possible and it may be interleaved with DCE experiments.