Abstract #0238

The Impact of Overall Injection Time on the Arterial Input Function and Pharmaco-Kinetic Analysis Using the Tofts Model in DCE-MRI for Prostate Cancer Patients

Andrea Holt¹, Edoardo Pasca¹, Stijn W. Heijmink², Jelle Teertstra², Sara H. Muller², Uulke A. van der Heide¹

¹Department of Radiation Oncology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, Netherlands; ²Department of Radiology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, Netherlands

In prostate cancer patients, we studied the effect of overall contrast agent injection time on the form of the arterial input function and on the outcome of pharmaco-kinetic analysis in healthy tissue. We found that below an overall injection time of 10 s no further sharpening of the first pass peak is observed.