In Vivo Reduction of Hyperpolarized [1-13C]-Dehydroascorbic Acid Is Affected by Glucose Transporter Expression

Sarah E. Bohndiek¹, ², Mikko I. Kettunen¹, ², David Lewis², Tiago B. Rodrigues¹, ², Ferdia A. Gallagher¹, ², Dmitry Soloviev², Kevin M. Brindle¹, ²

Hyperpolarized [1-¹³C]-Dehydroascorbic Acid (DHA) has recently been demonstrated as a novel imaging biomarker of tumor redox status in vivo. We show here that the rate of [1-¹³C]-DHA reduction is also influenced by glucose transporter expression, so care should be taken to assess the effect of DHA transport on imaging studies performed with this promising hyperpolarized probe.