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Abstract #0268

In Vivo Reduction of Hyperpolarized [1-13C]-Dehydroascorbic Acid Is Affected by Glucose Transporter Expression

SUMMA25Sarah E. Bohndiek1, 2, Mikko I. Kettunen1, 2, David Lewis2, Tiago B. Rodrigues1, 2, Ferdia A. Gallagher1, 2, Dmitry Soloviev2, Kevin M. Brindle1, 2

1Department of Biochemistry, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom; 2Cambridge Research Institute, Cancer Research UK, Cambridge, Cambridgeshire, United Kingdom

Hyperpolarized [1-13C]-Dehydroascorbic Acid (DHA) has recently been demonstrated as a novel imaging biomarker of tumor redox status in vivo. We show here that the rate of [1-13C]-DHA reduction is also influenced by glucose transporter expression, so care should be taken to assess the effect of DHA transport on imaging studies performed with this promising hyperpolarized probe.