Abstract #0269

In Vivo Imaging of Hyperpolarized 13C Labelled Choline & Monitoring of Metabolism

Trevor Wade¹,², Hyla Allouche-Arnon³,⁴, Lanette Friesen Waldner¹,⁵, Charles A. McKenzie¹,⁵, Kundan Thind¹,⁵, Alexei Ouriadov⁵, Albert Chen⁶, J. Moshe Gomori³, Rachel Katz-Brull³,⁴

¹Medical Biophysics, The University of Western Ontario, London, Ontario, Canada; ²XLR Imaging, London, Ontario, Canada; ³Department of Radiology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel; ⁴BrainWatch Ltd, Tel-Aviv, Israel; ⁵Robarts Research Institute, The University of Western Ontario, London, Ontario, Canada; ⁶GE Healthcare

The first noninvasive and nonradioactive imaging of choline labelled at position 1 with hyperpolarized ¹³C is presented as well as monitoring of its metabolism in a specific organ (the kidney) in the living rat. The chemical shift between choline and phosphocholine is sufficient to monitor the kinetics of choline metabolism using dynamic spectroscopy. Imaging and 2D CSI are also used to monitor regional choline uptake and the metabolic products.