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Abstract #0269

In Vivo Imaging of Hyperpolarized 13C Labelled Choline & Monitoring of Metabolism

MAGNA25Trevor Wade1, 2, Hyla Allouche-Arnon3, 4, Lanette Friesen Waldner1, 5, Charles A. McKenzie1, 5, Kundan Thind1, 5, Alexei Ouriadov5, Albert Chen6, J. Moshe Gomori3, Rachel Katz-Brull3, 4

1Medical Biophysics, The University of Western Ontario, London, Ontario, Canada; 2XLR Imaging, London, Ontario, Canada; 3Department of Radiology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel; 4BrainWatch Ltd, Tel-Aviv, Israel; 5Robarts Research Institute, The University of Western Ontario, London, Ontario, Canada; 6GE Healthcare

The first noninvasive and nonradioactive imaging of choline labelled at position 1 with hyperpolarized 13C is presented as well as monitoring of its metabolism in a specific organ (the kidney) in the living rat. The chemical shift between choline and phosphocholine is sufficient to monitor the kinetics of choline metabolism using dynamic spectroscopy. Imaging and 2D CSI are also used to monitor regional choline uptake and the metabolic products.