Abstract #0282

Inversion Recovery Sodium MRI of Cartilage in Controls & Patients with Osteoarthritis at 7T

Guillaume Madelin¹, Gregory Chang², Alexej Jerschow³, Ravinder R. Regatte²

¹Radiology, New York University, New York, NY, United States; ²Radiology Department, New York University Medical Center, New York, NY, United States; ³Chemistry Department, New York University, New York, NY, United States

Quantitative sodium MRI is highly specific to the glycosaminoglycan content in cartilage and could be used to assess the biochemical degradation of cartilage in early stages of osteoarthritis (OA). In this preliminary study we show that quantitative sodium MRI with fluid suppression by adiabatic inversion recovery reduces significantly the partial volume effect from synovial fluids or joint effusion in the measurements of sodium concentrations in articular cartilage, and therefore may allow to better differentiate OA patients from healthy controls.