Alena Horska1, Syed Hasan1, Xin Wang1, Matthew Ryan2, Richard Edden1, Martha Denckla2, Peter Barker1, 2, Mark Mahone, 12
1Johns Hopkins University, Baltimore, MD, United States; 2Kennedy Krieger Institute, Baltimore, MD, United States
Single voxel 1H MRS at 7T was used to measure glutamate concentrations in prefrontal and fronto-striatal regions in healthy 5-9 year old children. Reliability of glutamate measurement was assessed and the compliance with the MRI/MRS protocol was evaluated. Exploratory analyses were applied to examine the relationship between frontal Glu levels and neurobehavioral data.