Abstract #0295

Assessment of Prefrontal & Fronto-Striatal Glutamate Concentration in Healthy Children at 7T

Alena Horska¹, Syed Hasan¹, Xin Wang¹, Matthew Ryan², Richard Edden¹, Martha Denckla², Peter Barker¹,², Mark Mahone,¹²

¹Johns Hopkins University, Baltimore, MD, United States; ²Kennedy Krieger Institute, Baltimore, MD, United States

Single voxel 1H MRS at 7T was used to measure glutamate concentrations in prefrontal and fronto-striatal regions in healthy 5-9 year old children. Reliability of glutamate measurement was assessed and the compliance with the MRI/MRS protocol was evaluated. Exploratory analyses were applied to examine the relationship between frontal Glu levels and neurobehavioral data.