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Abstract #0295

Assessment of Prefrontal & Fronto-Striatal Glutamate Concentration in Healthy Children at 7T

Alena Horska1, Syed Hasan1, Xin Wang1, Matthew Ryan2, Richard Edden1, Martha Denckla2, Peter Barker1, 2, Mark Mahone, 12

1Johns Hopkins University, Baltimore, MD, United States; 2Kennedy Krieger Institute, Baltimore, MD, United States

Single voxel 1H MRS at 7T was used to measure glutamate concentrations in prefrontal and fronto-striatal regions in healthy 5-9 year old children. Reliability of glutamate measurement was assessed and the compliance with the MRI/MRS protocol was evaluated. Exploratory analyses were applied to examine the relationship between frontal Glu levels and neurobehavioral data.