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Abstract #0296

The Relationship between Glutamate & Oscillatory Activity in a Repetition Suppression Paradigm a Combined MR-Spectroscopy & EEG Study

Paul Gerald Mullins1, Corinna Haenschel2, Niall Lally, 13, Mark Roberts1, Darren Price, 14, Thomas Gruber5

1Psychology, Bangor University, Bangor, Gwynedd, United Kingdom; 2School of Psychology, City University, London, United Kingdom; 3ICN, London, United Kingdom; 4Nottingham University, United Kingdom; 5Institut fr Psychologie, Universitt Osnabrck, Germany

We present the first concurrently acquired event-related Magnetic Resonance Spectroscopy (MRS) and Electroencephalography (EEG) study of neuronal activity. Using a 3T MR system, and MRI compatible EEG simultaneous MRS (from the lateral occipital cortex) and EEG data were collected during an event related visual repetition suppression paradigm. Collecting proton MRS and EEG measures simultaneously showed a significant correlation between Glutamate levels and the gama band response, providing a new window on the underlying neurochemical and electrophysiological substrates of neuronal activity.