Abstract #0296

The Relationship between Glutamate & Oscillatory Activity in a Repetition Suppression Paradigm a Combined MR-Spectroscopy & EEG Study

Paul Gerald Mullins¹, Corinna Haenschel², Niall Lally,¹³, Mark Roberts¹, Darren Price,¹⁴, Thomas Gruber⁵

¹Psychology, Bangor University, Bangor, Gwynedd, United Kingdom; ²School of Psychology, City University, London, United Kingdom; ³ICN, London, United Kingdom; ⁴Nottingham University, United Kingdom; ⁵Institut fr Psychologie, Universitt Osnabrck, Germany

We present the first concurrently acquired event-related Magnetic Resonance Spectroscopy (MRS) and Electroencephalography (EEG) study of neuronal activity. Using a 3T MR system, and MRI compatible EEG simultaneous MRS (from the lateral occipital cortex) and EEG data were collected during an event related visual repetition suppression paradigm. Collecting proton MRS and EEG measures simultaneously showed a significant correlation between Glutamate levels and the gama band response, providing a new window on the underlying neurochemical and electrophysiological substrates of neuronal activity.