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Abstract #0297

Brain Metabolism in Glutamatergic & GABAergic Compartments Detected by in vivo 13C NMR Spectroscopy at 14.1 T

MAGNA25Joo M.N. Duarte1, 2, Rolf Gruetter1, 3

1Center for Biomedical Imaging, Ecole Polytechnique Federale Lausanne, Lausanne, Switzerland; 2Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland; 3Department of Radiology, Universities of Lausanne and Geneva, Lausanne and Geneva, Switzerland

We now investigated the metabolism of γ-aminobutyric acid (GABA) in the brain using localised 13C NMR spectroscopy at 14.1 T. Upon infusion of [1,6-13C]glucose, 11 time courses of 13C-enriched metabolites were quantified, to which we then fitted a 3-compartment model of cerebral metabolism, thus providing insight in GABA metabolism and GABAergic neurotransmission.