Abstract #0299

Myo-Inositol Increase with Age Shows SCN1A Dependency: A 3T MRS Study

Nuran Tunc-Skarka¹, Sandra Meier², Markus Sack¹, Wolfgang Weber-Fahr¹, Traute Demirakca¹, Thomas G. Schulze³, Carsten Diener⁴, Gabriele Ende¹

¹Neuroimaging, Central Insitute of Mental Health, Mannheim, Baden-Wrttemberg, Germany; ²Genetic Epidemiology in Psychiatry, Central Insitute of Mental Health, Mannheim, Baden-Wrttemberg, Germany; ³Psychiatry and Psychotherapy, University Medical Center Gttingen, Gttingen; ⁴Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Mannheim, Baden-Wrttemberg, Germany

Via MRS one of the most frequent findings in white matter of aging brains is a reduced NAA and an increased mI concentration. In our study we wanted to investigate if SCN1A has any effect on the age dependent metabolites in a sample of 49 healthy volunteers. SCN1A is been seen as a novel gene candidate for cognitive decline. We found reduced NAA and Glu and increased Cr and mI with age. Further we found increased mI in the SCN1A risk group.