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Abstract #0300

Measurement of Glycine in Gray & White Matter in the Human Brain by 1H-MRS at 7.0 T in vivo

Changho Choi1, Sandeep Ganji1, Abhishek Banerjee1, Ivan Dimitrov1, Subroto Ghose1, Carol Tamminga1

1University of Texas Southwestern Medical Center, Dallas, TX, United States

Measurement of glycine (Gly) in gray and white matter (GM and WM) in the human brain by 1H-MRS at 7T is reported. A Gly-optimized PRESS sequence was used for measuring Gly from various brain regions in 10 healthy volunteers. The Gly signal intensity, following the normalization to the water signal, was larger in GM-dominant regions than in WM-dominant regions. From a linear regression of the Gly estimates vs. fractional GM content, the Gly concentrations in GM and WM were estimated to be 0.99 and 0.04 mM, respectively.