Deqiang Qiu1, Greg Zaharchuk1, Thomas Christen1, Wendy W. Ni1, Michael E. Moseley1
1Radiology, Stanford University, Stanford, CA, United States
In this paper, we present the first human study of the use of ultrasmall superparamagnetic iron particle (USPIO) for contrast agent based blood Volume functional MRI (fBVI). The temporal response function of fBVI was characterized, and was found to include both a slow and a fast component. The contrast to noise ratio (CNR) of fBVI was found to be of up to a factor of 2.9 than the commonly used BOLD (Blood oxygenation level dependent) technique. The significant CNR gain with fBVI opens the possibility of high-resolution fMRI, including mapping of ocular orientation column in human.