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Abstract #0340

Magnetic Resonance BOLD & Diffusion Tensor Imaging for Diagnosis of Histopathological Changes in a Rat Model of Diabetic Nephropathy

MAGNA25Katja Hueper1, Dagmar Hartung1, Marcel Gutberlet1, Faikah Gueler2, Holger Sann3, Bettina Husen3, Frank Wacker1, Dania Reiche3

1Radiology, Hannover Medical School, Hannover, Germany; 2Nephrology, Hannover Medical School, Hannover, Germany; 3Abbott Products GmbH, Hannover, Germany

We investigated whether MR BOLD and diffusion tensor imaging (DTI) enables detection of renal pathologies in a rat model of diabetic nephropathy. Twenty-one rats (control; diabetes; diabetes with uninephrectomy, DM UNX) were examined by BOLD and echoplanar DTI (1.5T, b=0, 300 s/mm2, 6 diffusion directions). T2*-values, Fractional Anisotropy (FA) and ADC were compared to laboratory parameters and histology. T2*-values were not different between groups. However, in kidneys of DM UNX rats FA was significantly reduced and inversely correlated with glomerulosclerosis, interstitial fibrosis and tubular damage. Thus, MR DTI might be useful to noninvasively identify and monitor renal impairment in diabetes.