David
J. Niles1, Nathan S. Artz1, Elizabeth A. Sadowski2,
Arjang Djamali3, Thomas M. Grist1, 2, Sean
B. Fain1, 2
1Medical Physics, University of Wisconsin, Madison, WI, United States; 2Radiology, University of Wisconsin, Madison, WI, United States; 3Medicine, University of Wisconsin, Madison, WI, United States
Routine monitoring of renal function following transplantation is important for early detection of disease. In this study we used BOLD and ASL MRI to measure renal oxygenation and perfusion, respectively, in matched pairs of kidney transplant donors and recipients up to two years following transplantation. Statistically significant decreases in cortical perfusion and medullary oxygenation were observed in transplanted kidneys 3 months post-transplantation and remained present one year post-transplantation. Further measurements in this ongoing study will be used to statistically assess function two years post-transplantation.