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Abstract #0361

Highly Accelerated 3D Spiral Acquisition for Whole Brain Myelin Water Mapping Using a Hybrid SPIRiT-PCA Reconstruction

Thanh D. Nguyen1, Mitchell Cooper1, 2, Pascal Spincemaille1, Bo Xu1, 2, Ashish Raj1, Susan A. Gauthier3, Yi Wang1, 2

1Radiology, Weill Cornell Medical College, New York, NY, United States; 2Biomedical Engineering, Cornell University, Ithaca, NY, United States; 3Neurology and Neuroscience, Weill Cornell Medical College, New York, NY, United States

Recently an SNR efficient 3D T2prep spiral sequence has been developed to provide whole brain coverage in 24 min at 1.5T. We propose to develop a hybrid reconstruction method which combines Iterative Self-consistent Parallel Imaging Reconstruction (SPIRiT) and Principal Component Analysis (PCA) to exploit the spatiotemporal redundancy in multi-component T2 relaxometry to accelerate whole brain coverage from 24 min down to 6.5 min. Comparable myelin water fractions were obtained with the accelerated spiral data at 3T. SPIRiT-PCA may be a promising approach to bringing myelin quantification closer to clinical practice.