Abstract #0444

Quantification of Skeletal Muscle Perfusion Using Velocity Selective Arterial Spin Labeling at 3T

James Alastair Meakin¹,², Mark William Little³,⁴, Thomas William Okell¹, Suzie Anthony³, Raman Uberoi³, Peter Jezzard¹

¹FMRIB Centre, University of Oxford, Oxford, United Kingdom; ²Gray Institute for Radiation Oncology and Biology, University of Oxford, Oxford, United Kingdom; ³Department of Radiology, John Radcliffe Hospital, Oxford, United Kingdom; ⁴Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom

There is a need for accurate assessment of perfusion to lower limb skeletal muscle in patients with peripheral arterial disease to aid diagnosis and management. We have developed a Velocity Selective ASL (VSASL) sequence to provide quantitative measures of resting perfusion in calf skeletal muscle, without the transit delay errors associated with Continuous ASL. In this study, we optimised the acquisition and demonstrated the feasibility of VSASL for quantifying skeletal muscle perfusion at rest in five healthy volunteers.