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Abstract #0445

MR Skeletal Muscle Oximetry

Jie Zheng1, Xiaodong Zhang2, Hongyu An2, Andrew Coggan1, Adil Bashir1, Linda Peterson1, Robert J. Gropler1

1Washington University, Saint Louis, MO, United States; 2University of North Carolina, United States

A new non-contrast MRI oximetry method was presented to quantify absolute skeletal muscle O2 uptake. The feasibility of the method was evaluated in 7 normal volunteers, at rest and during an continuous isometric exercise. Two-fold increase in leg perfusion and significant decrease in oxygen extraction in skeletal muscle were observed with no apparent change in oxygen consumption, due to moderate exercise.