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Abstract #0460

Diffusion Enables the Distinction between Types of Tissue Microstructure by Analyzing the Water Lineshape

MAGNA25Alexander Ruh1, Philipp Emerich1, Dmitry S. Novikov2, Valerij G. Kiselev1

1Department of Radiology, Medical Physics, University Medical Center Freiburg, Freiburg, Germany; 2Center for Biomedical Imaging, Department of Radiology, NYU School of Medicine, New York, NY, United States

We show analytically and numerically, that the NMR spectral lineshape can distinguish between different kinds of global structural organization (order and various types of disorder) of tissue susceptibility. This distinction involves long-range correlations and is thereby robust to the biological variability. The biophysical mechanism behind this phenomenon is the molecular diffusion mediating the spin dephasing reflected in the transverse relaxation. Our results provide a framework for novel types of susceptibility-based contrast.