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Abstract #0462

In-Vivo Angular Double-PFG MRI of the Human Brain

Carl-Fredrik Westin1, Markus Nilsson2, Ofer Pasternak3, Daniel Topgaard4, Hans Knutsson5

1Department of Radiology , BWH, Harvard Medical School, Boston, MA, United States; 2Department of Medical Radiation Physics, Lund University, Lund, Sweden; 3Department of Radiology, BWH, Harvard Medical School, Boston, MA, United States; 4Division of Physical Chemistry, Lund University, Lund, Sweden; 5Department of Biomedical Engineering, Medical Informatics, Linkping University, Linkping, Sweden

Previous experimental results demonstrate that angular double-PFG analysis alleviates the demand for strong gradients for microstructure determination and that estimation of novel features of tissue that displays a microscopic anisotropy may be possible using clinical scanners. We here present new data supporting this claim. The presented work shows that it is possible to perform in vivo double PFG imaging of the human brain with a good SNR, indicating that the new the microstructural contrasts from double-PFG can be made available to studies of clinical populations.