A Turn-Key Solution for the Quantification of Brain Oxygen Metabolism

Peiying Liu¹, Feng Xu¹, Hanzhang Lu¹

Cerebral metabolic rate of oxygen (CMRO2) is an important index of tissue viability and brain function. Previous MRI measurements of CMRO2 are not yet widely available for clinical applications due to various technical and feasibility reasons. The present study proposed a turn-key solution for quantitative assessment of global CMRO2. While the lack of spatial resolution is the main limitation of the proposed method, it is non-invasive (no exogenous agent), fast (<5 min in scan time), and reliable (Coefficient of variation<3%) and can be performed on a standard clinical scanner. These features afford this technique great potentials for immediate clinical applications.