Voxel-Based Structural & Functional MRI Pattern Recognition & Correlation in Multiple Sclerosis (MS)

Yongxia Zhou¹, Joseph Herbert¹, Hina Jaggi¹, Robert I. Grossman¹, Yulin Ge¹

Voxel-based whole brain analyses were used to assess spatial distribution of lesion probability (on FLAIR), regional atrophy (using voxel-based morphometry on MPRAGE), microstructural damage (tract-based spatial statistics using diffusion tensor imaging), and interhemispheric synchronization disruption (voxel mirrored homotopic correlation using resting state fMRI) in 16 MS patients and 16 controls. We demonstrated specific abnormality patterns underlying different pathological processes in both gray matter and white matter and their regional likelihood on each quantitative measure. The structural and functional measures are complementary to each other in understanding the complicated disease processes of MS.