Abstract #0575

Noninvasive Characterization of Lymphatic Flow Velocity Using Principles of Spin Labeling

Swati Rane¹, Paula Donahue², John Jordi³, John C. Gore¹,⁴, Manus Donahue¹

¹Radiology and Radiological Sciences, Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States; ²Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN, United States; ³Lymphedema Clinic, Siskin Hospital, Chattanooga, TN, United States; ⁴Biomedical Engineering, Vanderbilt University, Nashville, TN, United States

The aim of this study is to exploit principles of spin labeling to magnetically label water in human lymphatic fluid and for the first time noninvasively characterize the flow of lymphatic fluid to lymph nodes. We report quantitative measures of 3T lymphatic T₁ (3117158 ms) and T₂ (60512 ms) and use pulsed spin labeling principles in conjunction with parallel-transmit technology to quantify lymphatic flow velocity (5.9 cm/min) in healthy volunteers. Results outline the potential for lymphedema risk to be assessed in patients following axillary node removal by identifying and monitoring the compromised lymphatic flow patterns in preclinical stages of disease.