Andrea Bianchi1, Franois Lux2, Gael Dournes1, Olivier Tillement2, Yannick Crmillieux1
1Center of Cardio-Thoracic Research, University of Bordeaux Segalen, Bordeaux, France; 2Laboratoire de Physico-Chimie des Matriaux Luminescents, Universit Lyon 1, Lyon, France
In this study we present the MRI investigation of the T1-enhancement of the lung signal due to the intra-tracheal administration of different concentrations of a silica-based gadolinium contrast agent, characterized by ultra-small nanoparticles and high relaxivity. The MRI investigation of the temporal evolution of the signal enhancement is also presented to get an estimate of the contrast agent residence time in the lungs. Notably high signal enhancements (> 200% for a 50 mM solution) with relatively small instilled volumes (50 l) have been measured thanks to the high S/N and the negligibility of motion artifacts, typical of the UTE sequence.