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Abstract #0629

Hyperpolarized Xe-129 CSI of the Human Lung: Preliminary Results from Healthy, Second-Hand Smoker & Cystic-Fibrosis Subjects

Sara Reis1, 2, Kai Ruppert1, Talissa Altes1, John Mugler III1, Iulian Ruset3, Wilson Miller1, William Hersman3, Jaime Mata1

1Radiology & Medical Imaging, University of Virginia, Charlottesville, VA, United States; 2IBEB - FCUL, Universidade de Lisboa, Lisboa, Portugal; 3Xemed, NH, United States

From the Xe-129 CSI data, we directly calculate image-maps reflecting the amount of Xe-129 in the airspaces (gas), and dissolved in the lung tissue (parenchyma/plasma), red-blood-cells (RBC), and other compartments, thus obtaining detailed spatial information regarding how Xe-129 is distributed in these multiple compartments and providing regional information about lung physiology.