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Abstract #0630

Hyperpolarized Helium-3 & Xenon-129 Magnetic Resonance Imaging of Elderly Never-Smokers & Ex-Smokers with Chronic Obstructive Pulmonary Disease

SUMMA25Miranda Kirby1, 2, Andrew Wheatley1, Adam Farag1, Alexei Ouriadov1, Giles E. Santyr1, David G. McCormack3, Grace Parraga1, 2

1Imaging Research Laboratories, Robarts Research Institute, London, ON, Canada; 2Medical Biophysics, The University of Western Ontario, London, Ontario, Canada; 3Division of Respirology, Department of Medicine, The University of Western Ontario

The objective of this study was to compare hyperpolarized helium-3 (3He) and hyperpolarized xenon-129 (129Xe) magnetic resonance imaging (MRI) in chronic obstructive pulmonary disease (COPD) ex-smokers and age-matched never-smokers. 3He and 129Xe images were segmented using image segmentation/registration software. In 10 COPD subjects and 8 never-smokers, 129Xe ventilation defect percent (VDP) was statistically significantly higher than 3He VDP (p<.0001). This finding suggests that 129Xe may be more sensitive to the structural alternations that occur in the distal terminal and respiratory bronchioles and is a feasible alternative to 3He MRI with strong translational potential in COPD studies.