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Abstract #0693

Whole-Brain DSI in 4 Minutes: Sparse Sampling in Q-Space with Simultaneous Multi-Slice Acquisition

Kawin setsompop1, Berkin Bilgic2, Julien Cohen-Adad1, M. Dylan Tisdall1, Boris Keil1, Thomas Witzel1, Yogesh Rathi3, Van J. Wedeen1, 4, Elfar Adalsteinsson2, 4, Lawrence L. Wald1, 4

1Dept. of Radiology, A. A. Martinos Center for Biomedical Imaging, MGH, Charlestown, MA, United States; 2EECS, Massachusetts Institute of Technology, Cambridge, MA; 3Brigham and Women's Hospital, Boston, MA, United States; 4Harvard-MIT Division of Health Sciences and Technology

In this work, we demonstrate an improvement in the time efficiency of DSI acquisitions using three complementary technologies: (i) high-strength gradient coils, (ii) a Simultaneous Multi-Slice (SMS) acquisition with Blipped-CAIPI readout using a highly parallel receive coil array, and (iii) a compressed sensing reconstruction that enables undersampling of q-space. Together, these improvements allow for an acquisition of high-quality whole-brain DSI data in just over 4 minutes. While this initial demonstration focuses on DSI, the general approach should be applicable to other HARDI acquisition schemes.