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Abstract #0728

Toxicity of Mn2+ in MEMRI with Topical Loading

SUMMA25Tsen-Hsuan Lin1, Sheng-Kwei Song2

1Physics , WUSTL, St Louis, MO, United States; 2Radiology, Washington University in St Louis, St Louis, MO, United States

Manganese enhanced MRI (MEMRI) with topical loading is a novel approach to investigate anterograde axonal transport of the visual pathway. There is no need to perform intraocular injection physically damaging the eye. Topical loading has been demonstrated to produce similar MEMRI results as with intraocular injections. However, it is still uncertain if visual function is affected after MnCl2 loading. This study determined the minimum dosage for the success MEMRI and measured the visual function after MnCl2 loading. Mouse vision was affected but slowly recovered with 0.75M MnCl2 loading. Based on DTI parameters of optic nerve and T2W images of retina, the injured retina is likely the cause of the impaired visual function.