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Abstract #0729

Highlighting Manganese Transport Mechanisms in the Nervous System with MEMRI in Aplysia Californica

SUMMA25Ileana Ozana Jelescu1, Romuald Nargeot2, Denis Le Bihan1, Luisa Ciobanu1

1NeuroSpin, CEA/DSV/I2BM, Gif sur Yvette, France; 2Universit Bordeaux 1, CNRS UMR 5287, Bordeaux, France

Manganese is increasingly used as a neuronal tract tracer but its exact transport pathways are yet to be identified. Aplysia californica provides an ideal framework of identified and large neurons to explore this matter. We performed MEMRI on its buccal ganglia to study the Mn2+ transport in resting state and following dopamine (DA)-induced activation. We confirmed, for the first time using MEMRI, the known axonal projections of identified motor neurons in the peripheral nerves of the ganglia. Images following DA perfusion showed intercellular Mn2+ transport with activation. The synapses involved are to be confirmed by ongoing experiments.