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Abstract #0730

Evaluation of Functional Connectivety in a Cold-Microtubule Deficient Mice Using Manganese Enhance Magnetic Resonance Imaging in vivo

MAGNA25Alexia Daoust1, 2, Emmanuel Luc Barbier1, 2, Annie Andrieux1, 2, Sylvain Bohic3, 4, Jean-Christophe Deloulme, 23

1INSERM, U836, Grenoble, France; 2Universit Joseph Fourier, Grenoble Institut des Neurosciences, Grenoble, France; 3INSERM , U836, Grenoble, France; 4European Synchrotron Radiation Facility, Grenoble, France

Stable tubule only polypeptide deficient mice (STOP KO) are devoid of cold stable microtubule, which induces a synaptic deficit. In this study, we evaluate the cortical projections in these mice and in the corresponding wild type: functionally, using MEMRI (between 2 and 24h after intracortical injections) and structurally using gold staining histology. We observed that the functional deficits observed (long-range projections) are not correlated to structural deficit (reduction in tract size).