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Abstract #0744

Effect of Saturation Pulse Length on Parallel Transmission Based Amide Proton Transfer (APT) Imaging of Different Brain Tumor Types

MAGNA25Osamu Togao1, Takashi Yoshiura1, Jochen Keupp2, Akio Hiwatashi1, Koji Yamashita1, Kazufumi Kikuchi1, Yuriko Suzuki3, Koji Sagiyama4, Masaya Takahashi4, Hiroshi Honda1

1Clinical Radiology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan; 2Philips Research, Hamburg, Germany; 3Philips Electronics, Japan; 4Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States

Amide proton transfer (APT) imaging employs the exchange between protons of free tissue water and the amide groups (-NH) of endogenous mobile proteins and peptides, imaged by a saturation transfer technique. In this imaging technique, the length of RF saturation (Tsat) is an important parameter for sensitivity. A technique based on parallel RF transmission was demonstrated, which allows arbitrarily long RF pulses (~5s) via amplifier alternation in clinical scanners. We evaluated the Tsat dependence of the APT contrast in human brain tumors and to demonstrate the efficacy of long Tsat achieved by the parallel RF transmission based technique.