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Abstract #0745

RF Power Dependence of Human Brain CEST, NOE & Metabolite MT Effects at 7T

MAGNA25Dapeng Liu1, Jinyuan Zhou2, 3, Rong Xue1, Zhentao Zuo1, Jing An4, Danny JJ Wang5

1State Key Lab. of Brain and Cognitive Science, Beijing MRI Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China; 2FM Kirby Center, Kennedy Krieger Institute, Baltimore, MD, United States; 3Department of Radiology and Radiological Sciences, Johns Hopkins Medical Institutes, Baltimore, MD, United States; 4Siemens Shenzhen Magnetic Resonance Ltd, Shenzhen, China; 5Neurology, UCLA, Los Angeles, CA, United States

In this work we investigated the RF power dependence of the magnetization transfer (MT) asymmetry effects at 7T. The results suggest that at low B1, the nuclear Overhauser enhancement (NOE) and metabolite MT effects are the dominant source of MT asymmetry while at higher B1, the amide proton transfer (APT) effect becomes stronger and finally reverses the asymmetry plot. Our results suggest that MT asymmetry at 7T with low B1 may provide an approach for in vivo imaging of brain lipid (e.g., myelin).