Rhoshel Lenroot1, 2, Pui Ka Yeung2, Gloria Roberts1, Clare McCormack1, Michael Breakspear1, 3, Melissa Green1, Andrew Frankland1, Adam Wright1, Phoebe Lau1, Florence Levy1, Herng Chan1, Dusan Hadzi-Pavlovic1, Philip Mitchell1
1University of New South Wales, Randwick, NSW, Australia; 2Neuroscience Research Australia, Randwick, NSW, Australia; 3Queensland Institute of Medical Research
Characterization of brain morphometry in individuals at elevated genetic risk for Bipolar Affective Disorder may illuminate early stages of the disorder and identify potential endophenotypes. Structural MRI images were acquired in 85 adolescents and young adults at elevated genetic risk for BPD and 84 matched control subjects. Brain volumes, cortical surface area and thickness were examined using an automated method. At-risk subjects had increased brain volumes and surface area, including regions such as the anterior cingulate and insula, but cortical thickness was not different. These finding suggest surface area may be a useful endophenotype for genetic studies of BPAD.