Study of Prefrontal Cortical Metabolism in Stressed and Resilient Mice in Social Defeat Model of Depression

Anant Bahadur Patel¹, Pandichelvam Veeraiah¹, Judith Noronha¹, Puneet Bagga¹, Arvind Kumar¹

Mechanisms responsible for the abnormal glutamate and GABA level in the brain of depressed patients remain to be understood. Current study investigate cerebral metabolism in prefrontal cortex of depressed and resilient mice. Level of glutamate, aspartate, taurine and choline was found to be decreased in depressed mice while resilient mice showed increased GABA without any change in other neurometabolites. Depressed mice are associated with reduced glutamatergic and GABAergic activity.