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Abstract #0804

Spontaneous Depolarization Waves in Medetomidine Sedated Sprague-Dawley Rats Detected by FMRI

SUMMA25Artem Shatillo1, Joanna Huttunen1, Antti Airaksinen1, Juha-Pekka Niskanen1, 2, Olli Grohn1

1Department of Neurobiology, University of Eastern Finland, Kuopio, Finland; 2Department of Applied Physics, University of Eastern Finland, Kuopio, Finland

Spreading depolarization (SD) waves are typically observed only under pathophysiological conditions. We detected spontaneously occurring SDs in 9 Sprague-Dawley rats during 1 hour long BOLD fMRI study under medetomidine sedation. Total of 17 waves were detected lasting for 193.3 58.8 sec in one cortical ROI, propagating with speed of 2.930.6 mm/min. Observed propagation pattern and involvement of subcortical regions is atypical for classical spreading depolarization described in literature and needs further investigations.