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Abstract #0803

Improved DMN Connectivity in Patients with Unilateral Stenosis of Internal Carotid Artery After Carotid Stent Placement: A Resting-State FMRI Study

MAGNA25Feng-Xian Yan1, Tsong-Hai Lee2, Ho-Fai Wong3, Ho-Ling Liu1, 3

1Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan; 2Department of Neurology and Stroke Center, Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan; 3Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Taoyuan, Taiwan

This study aimed to investigate the default-mode network (DMN) and task-positive network (TPN) connectivity changes in patients with unilateral internal carotid artery stenosis before and after carotid stent placement. Sixteen patients underwent resting-state (RS) fMRI and DSC perfusion MRI scans one week before and six months after stenting. RS functional images were analyzed with seeds defined as a spherical ROI within PCC and a PCC mask. This study found impaired functional connectivity in DMN and TPN, which could recover after the stenting. The results were not directly related to regional perfusion deficits and thus likely linked to the neuronal origins.