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Abstract #0819

Total Sodium Concentration Is Increased in Lesions and Normal Appearing White Matter in Multiple Sclerosis

David Paling1, Bhavana Solanky1, Frank Riemer1, Claudia AM Wheeler-Kingshott1, Raju Kapoor1, David H. Miller1, Xavier Golay2

1NMR Research Unit, Department of Neuroinflammation, UCL Institute of Neurology, London, United Kingdom; 2NMR Research Unit, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom

Mapping total sodium concentration in multiple sclerosis (MS) may be a useful method of assessing pathophysiological processes including increase in intracellular sodium concentration, and increase in proportion of higher sodium concentration extracellular fluid from axonal loss.