Abstract #0819

Total Sodium Concentration Is Increased in Lesions and Normal Appearing White Matter in Multiple Sclerosis

David Paling¹, Bhavana Solanky¹, Frank Riemer¹, Claudia AM Wheeler-Kingshott¹, Raju Kapoor¹, David H. Miller¹, Xavier Golay²

¹NMR Research Unit, Department of Neuroinflammation, UCL Institute of Neurology, London, United Kingdom; ²NMR Research Unit, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom

Mapping total sodium concentration in multiple sclerosis (MS) may be a useful method of assessing pathophysiological processes including increase in intracellular sodium concentration, and increase in proportion of higher sodium concentration extracellular fluid from axonal loss.