Combining SIENA & SIENAx for Improved Quantification of Grey and White Matter Atrophy

Mishkin Derakhshan¹, Sridar Narayanan¹, D. Louis Collins¹, Douglas L. Arnold¹

We propose a novel technique for a more sensitive measurement of tissue-specific atrophy by combining the precise, longitudinal edge-displacement approach of SIENA with the tissue classification feature of SIENAx. The method is evaluated using (1) scan-rescan data and (2) simulated atrophy data and (3) is applied to a multi-centre relapsing-remitting multiple sclerosis dataset.