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Abstract #0821

Lesion Morphology at 7 Tesla MRI Differentiates Susac Syndrome from Multiple Sclerosis

Tim Sinnecker1, Jens Wuerfel1, 2, Thoralf Niendorf3, Friedemann Paul1, 4, Ilka Kleffner5, Jan Drr1, 4

1NeuroCure Clinical Research Center, Charit-Universittsmedizin Berlin, Berlin, Germany; 2Institute of Neuroradiology, University of Luebeck, Luebeck, Germany; 3Berlin Ultrahigh Field Facility, Max Delbrueck Center for Molecular Medicine, Berlin, Germany; 4Clinical and Experimental Multiple Sclerosis Research Center, Charit-Universittsmedizin Berlin, Berlin, Germany; 5Department of Neurology, University of Mnster, Mnster, Germany

Clinical and paraclinical findings including MRI findings at 1.5 T MRI in Susac syndrome often enough overlap with respective findings in MS. In fact, many patients with Susac syndrome are misdiagnosed as having MS. Realizing the brilliant signal to noise ratio at 7 T, we here studied 4 patients affected with Susac syndrome, and report substantial differences in both deep white matter and corpus callosum lesion morphology between Susac syndrome and MS. Our data i) suggest that lesion morphology at 7T supports differentiation between Susac syndrome and MS and ii) provide new insights into the pathophysiological mechanism underlying Susac syndrome.