Gianna Riccitelli1, Maria A. Rocca1, Elisabetta Pagani1, Vittorio Martinelli2, Marta Radaelli2, Andrea Falini3, Giancarlo Comi2, Massimo Filippi1
1Neuroimaging Research Unit, Institute of Experimental Neurology, San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy, Italy; 2Department of Neurology, San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy, Italy; 3Department of Neuroradiology, San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy, Italy3
We assessed the correlation between the regional distribution of gray matter (GM) atrophy and performances at the symbol digit modalities (SDMT) and paced auditory serial addition (PASAT) tests in 51 relapsing remitting multiple sclerosis (RRMS) patients. PASAT scores were correlated with GM atrophy in the caudate nuclei, the cerebellum and several regions mainly located in the fronto-temporo-parietal lobes, while SDMT scores were correlated with GM atrophy in the left cingulum, the parietal lobes and the bilateral cerebellum. The results suggest that deficits at SDMT and PASAT are associated to distinct patterns of regional distribution of GM atrophy in RRMS.